We have innovations in airway remodelling and lung fibrosis with a goal to develop more complex inflammatory and fibrotic human in vitro lung models. Work in this area is in its infancy and generally poorly defined. These models will focus on endpoints of biopersistancy for:
CHEMICAL INTERACTIONS
To assess chemical degradation in mucus or surfactants
PHYSICAL INTERACTIONS
Depending on the location of airway deposition, the physical interactions with mucus or surfactant, e.g., dissolution, degradation and coating, induce varying responses and cell mediator communications
BIOLOGICAL INTERACTIONS
Cellular interaction cascade responses are under research with airway cells (epithelial and alveolar macrophages) to measure cellular processes and fate (phagocytosis, uptake), with the need to gauge secondary cellular interactions from fibroblasts mesothelial cells
