AIRWAY DISEASE MODELS

AIRWAY DISEASE MODELS

We have innovations in airway remodelling and lung fibrosis with a goal to develop more complex inflammatory and fibrotic human in vitro lung models. Work in this area is in its infancy and generally poorly defined. These models will focus on endpoints of biopersistancy for:

CHEMICAL INTERACTIONS

To assess chemical degradation in mucus or surfactants

PHYSICAL INTERACTIONS

Depending on the location of airway deposition, the physical interactions with mucus or surfactant, e.g., dissolution, degradation and coating, ​induce varying responses and cell mediator communications

BIOLOGICAL INTERACTIONS

Cellular interaction cascade responses are under research with airway cells (epithelial and alveolar macrophages) to measure cellular processes and fate (phagocytosis, uptake), with the need to gauge secondary cellular interactions from fibroblasts mesothelial cells

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