Authors: Jan Turner, Pandora Pound, Carla Owen, Isobel Hutchinson, Marina Hop, David Y. S. Chau, Lady V. Barrios Silva, Mike Coleman, Audrey Dubourg, Lorna W Harries, Victoria Hutter, J. Gerry Kenna, Volker M. Lauschke, Winfried Neuhaus, Clive Roper, Paul B. Watkins, Jonathan Welch, Laura Rego Alvarez and Katy Taylor
Publication: High content analysis of in vitro alveolar macrophage responses can provide mechanistic insight for inhaled product safety assessment
Authors: V.Hutter, S.Hoppercd, J.Skamarauskas, E.Hoffman
RESULTS DELIVERED BY A PARTNERHIP BETWEEN SCIENCE AND LOGISTICS
We work hard at ImmuONE to provide quality products and testing services for clientele all around the world. Our innovative in vitro solutions help consumers by providing relevant and reliable endpoints to support the decision-making process and improve risk assessment approaches. The therapeutics, consumer products, and chemical industries are just a few examples. Our clients can work with us regardless of location, no distance is too far. So, the question is, how do we do it?
Taking the stress out of our work
Working hand in hand with our logistics partner, YSDS, is a game changer. Just because a business is not local, does not mean we can’t provide outstanding service. Forming an alliance with a professional logistics team has proven to be advantageous for our customers. Our study proposals now include shipping costs, removing all the tedious admin work required when sending test items, compounds, or biological samples. We agree a collection date with our client and that’s it! The shipment is treated with care and consideration, without increasing their workload. Working with YSDS allows both parties unprecedented improvements in shipping efficiency without compromising on quality or adding to costs.
Expert solution to a sensitive problem
The models we prepare include specialised, sensitive cells. To accurately represent human physiology, the cells need to be viable outside of the body… therefore they have special requirements. These include being temperature specific, stored carefully, handled appropriately, and transported within a certain time frame.
Delivering our services to the world
Shipping such biological and chemical items outside the UK presents issues and delays. This is where YSDS have also added value; a professional and experienced logistics team, qualified for the movement of chemicals and biological samples globally. They offer temperature- sensitive logistics monitored throughout the journey, ensuring that immediate action can be taken if there is the slightest deviation. Their experts plan the safest routes and provide risk assessments; with the ability to intervene if they see any potential delays on the horizon. The high level of service, use of the latest shipping technology, and detailed planning have proven to be advantageous. This would be hugely time consuming for both ImmuONE and our clients, but ultimately it is crucial to success.
Meeting the standards our clients deserve
Just as our products are developed carefully by expert scientists, so our logistics must match this. YSDS logistics solutions are GDP-certified and follow ISO 9001 standards. Compromised products can cause more harm than good when used for assessment, so it is crucial to invest in premium logistics methods. The attention our products receive from YSDS ensures that the quality of our products is not impacted by the risks of shipping, or the burden of never-ending paperwork, giving our team more time to work on new innovative products.
Most importantly, the relationship with YSDS makes the process seamless, both for us and our clients, ensuring that we all remain informed, every step of the way.
CRACK IT Challenge 36: Winners Phase 2
Following successful completion on the phase 1 challenge awarded to ImmuONE by the NC3Rs, we were announced as the winners for the phase 2 challenge in Jan 2022. Sponsored by Unilever and AstraZeneca the project aims to establish and develop in vitro OECD test guideline assays; free from animal-derived products and demonstrate their equivalence and superiority to current strategies. Once optimised, these technologies will be progress to a commercially ready, human relevant, animal-free bioassays with the view to gaining regulatory acceptance.
CRACK IT Challenge 36: Animal-free in vitro
We are excited to announce that ImmuONE was awarded funding to carry out the six-month proof-of-concept studies in Phase 1 of this year’s CRACK IT Challenges competition organised by the NC3Rs. Sponsored by Unilever and AstraZeneca, this challenge aims to adapt established OECD test guidelines for in vitro assays so that they are free from animal-derived products to improve human relevance and reproducibility and help drive the uptake of animal-free reagents.
Dr Victoria Hutter, CSO at ImmuONE is leading a multi-disciplinary consortium including PAN Biotech and the University of Oxford to answer this challenge. The team combines expertise in serum replacement, in vitro innovations and pre-clinical assessment to develop these solutions into marketable products and services that will have a significant impact on the 3Rs across the bioscience sector.
“It’s wonderful to be working with such a skilled and focussed team to address this Challenge,” says Victoria. “The NC3Rs, Unilever and AstraZeneca have put forward a very pertinent Challenge in the bioscience industry and we’ve put together a team that spans the breadth of expertise from innovators to end users to address it. As a result, we hope the benefits of entirely animal-product free approaches will be realised across the sector.”
One of the ultimate goals of the full Challenge is to deliver adapted OECD test guideline protocols which are free from animal-derived products and can be transferred to other laboratories to facilitate industry uptake.
“Whilst animal-free alternatives for cell culture and biological assessment exist, unfortunately their uptake by the scientific community has been slow,” says Victoria. “We aim to change this and demonstrate that completely animal product-free alternatives are possible and equivalent or better to standard animal product-containing reagents.”
CASE STUDY: ImmuONE Making Each Breath Safer
Our co-founder Abigail Martin spoke with Set Squared about her journey from PhD student to building ImmuONE. This case study provides an outline of how ImmuONE was started and our expertise in human in vitro cell culture solutions for safety assessment. We take 23,000 breaths every day and the products we are developing help make those breaths safer for our bodies. Investment from ICURe was the first step in our journey and led to the discovery of how our products could make an impact within the biotech market and to various industries. Read more of our journey by clicking on the image below.
Set Squared is a unique enterprise partnership and collaboration between the UK’s leading research universities of Bath, Bristol Exeter, Southampton, and Surrey, who support projects and help turn these into thriving businesses.
ImmuONE awarded £35k ICURe funding
University of Hertfordshire PhD student Abigail Martin has returned from the trip of a lifetime, after exhibiting her cutting-edge health technology research across the world.
Abigail’s PhD research project has led to the development of a 3D model human lung that can be grown in a laboratory. The technology allows for the respiratory testing of any sort of chemical or particles that we might inhale. Scientists and researchers can use the test results to measure the extent of the damage that these substances can cause and determine the concentration that might be considered safe. This has worthwhile potential applications across a range of industries relating to pollution, agricultural chemicals, asthma, paint inhalation, as well as minimising the use of animal testing.
Abigail was accepted into Innovate UK’s Innovation to Commercialisation of University Research (ICURe) programme for the South England region after being approached by University of Hertfordshire Associate Dean (Business and Enterprise), Prof. Darragh Murnane, to apply. The ICURe journey began with an intensive 12 week programme that enables a cohort of innovators to validate a market for their technology.
“The programme starts with a week long intensive bootcamp,” says Abigail. “You’re given support with deciding the value proposition of your technology and advice on how to network with people to encourage you to actively go out and spread the word about it. You then do a pitch for a significant amount of funding to be used to travel the world and talk about your technology. After being successful in my pitch, I put together a schedule of tradeshows and exhibitions that I identified as addressing my key markets, and I set off.”
Abigail went on to make connections across four continents, visiting eight countries including the United States of America, France, Spain, Scotland and Belgium and taking part in upwards of 120 meetings, all of which enabled her to speak specifically to relevant contacts within the life sciences and pharmaceutical markets.
“In academia you don’t usually get a chance to go out and test if there is a market for academic inventions, and the opportunity to do this was invaluable in letting me evaluate my technology and how it might be used. I got to exhibit at tradeshows and industry conferences attended by anywhere between 100 and 45,000 people and ask them about the problems they face with current lung models, what works and doesn’t work for them, and identify ways in which we could improve the technology.”
“The experience itself was so empowering. At first it was challenging to gain the confidence to approach people and be assertive, especially coming in as a young female in quite a male dominated industry. But over the course of the programme and my time abroad, my confidence grew a lot and people were really welcoming and open to hearing from me. It was a great feeling, being able to bridge the gap between academia and industry.”“It was really reassuring to see that 25 percent of my ICURe cohort was female. We need to see more women and young people out there pushing their technologies and themselves.”Following the 12 week programme, Abigail delivered a pitch to Innovate UK and venture capitalists in order to progress into the next step of the programme. “After receiving positive feedback on my pitch, Innovate UK provided me with another 3 month salary and I was able to attend another business bootcamp, preparing me to move past market validation and into writing a business plan and raising capital.”
Don Spalinger, Director SETsquared ICURe Programme, said: “Abigail really exemplified what we have developed the SETsquared ICURe programme to do, which is to get the researchers out of the lab and into the marketplace to validate that their research results are addressing burning needs. She embraced the training she was given at the ICURe Bootcamp and then went out and held over 100 discussions with companies. She found that a number of these companies really needed the 3D human lung model, and she is now moving forward in commercialising it.”New Paragraph
The next steps towards commercialisation
As she works towards completing her PhD, Abigail has also submitted an application for another Innovate UK competition for follow-on funding, with the help of her PhD Supervisor Dr. Victoria Hutter and the University’s Business Development team.
“This round of funding would provide up to £300k! We’re hoping that with the further investment, we’ll be able to launch a spin out company from the technology, or if not, license it out. This isn’t something I would have been able to do, especially so quickly, had I not taken part in the ICURe programme. It enabled me to build on my entrepreneurial skills and in fact, I was being approached with job opportunities almost weekly, from people that I met at various conferences and events. I would definitely recommend it.”
Prof. Darragh Murnane, commented: “The University is proud to support talented researchers like Abigail in the development of their technologies and innovations, with real world implications. We’re huge advocates of inspiring our students to look beyond the realms of academia and to be enterprising and industry driven; Abigail is a perfect example of how rewarding and successful this can be.”
Original article can be found here.