RELIABLE, REPRODUCIBLE, ROBUST: HIGH CONTENT IMAGE ANALYSIS OF THE LUNG
morph_ONE is a mechanistic-driven assay that reveals how inhaled substances affect more morphological and biochemical features of alveolar macrophages, that correlate to in vivo endpoints.
The assay helps companies and researchers to correctly interpret the response of the immune system in the lungs to inhaled chemical products, improving product development.
This has the potential to offer an early pre-clinical screening tool to predict the safety profile of novel inhaled medicines and prevent unsuitable compounds entering in vivo animal testing. Prediction of foamy macrophage responses at the in vitro level will better inform animal experiments required to achieve an accurate predication of the safety of new inhaled medicines in humans, with the goal of reducing our reliance on in vivo experiments.
The comparison of in vitro cell responses from a variety of rat ex vivo and human and rat in vitro models allows for a direct comparison between species.