ImmuPHAGE™ represents functional alveolar-like macrophages in vitro.
It consists of human alveolar-like cells which closely resemble the features of alveolar macrophages found in the deep lung, such as the ability to elicit an immune mediated response to inflammatory modulators and alveolar clearance of particulate material.
The standardised model is fully validated and characterised in terms of morphology, viability, phagocytic activity and cytokine response. ImmuPHAGE™ can provide highly reproducible toxicological information and detailed mechanistic understanding of the safety and fate of inhaled substances in the lungs.
Morphology of ImmuPHAGE™ (left) closely resemble primary human alveolar macrophages (right)